Evaluation of the Efficacy of Tiamulin
in the
Prevention of a Model Infection with Mycoplasma gallisepticum in Chickens
by
Stipkovits, L.* and Burch, D.G.S.**
*Veterinary Medical Research Institute, Budapest, Hungary
**Novartis Animal Health, Camberley, Surrey, UK
Proceedings of the XIth World Veterinary Poultry Association Congress, Budapest, Hungary (1997) p81
Abstract:
Valnemulin (EconorŽ - Novartis) was compared with a number of antimycoplasmal agents: tiamulin hydrogen fumarate (TiamutinŽ - Novartis), tylosin, tilmicosin, lincomycin/spectinomycin, enrofloxacin and chlortetracycline in an artificial Mycoplasma gallisepticum (MG) infection study in chicks. The birds, aged 14 days, were weighed and allocated to each treatment group (10 / group) including an untreated control and injected with a culture of MG into the left air sac. Treatment was given for 3 days in the drinking water and the birds were monitored for a further 7 day period prior to autopsy. The birds were weighed again and air sacs were cultured for MG and lesions scored. The feed consumption during the trial was recorded and the feed conversion efficiency (FCE) calculated.
Results:
The results are summarised in Table 1 and Graph 1 & 2.
Table 1. Summary of the trial results
Treatment group
(ppm in drinking water)
|
Air sac
lesion score (%)
|
MG re-isolation (%)
|
ADG (g)
|
Improvement (%)
|
FCE
|
Improvement (%)
|
Infected untreated control
|
100
|
100
|
21.5
|
-
|
2.79
|
-
|
Tiamulin 125
|
8
|
40
|
32.6
|
52
|
1.90
|
32
|
Tiamulin 250
|
3
|
10
|
25.7
|
20
|
2.49
|
11
|
Valnemulin 125
|
11
|
10
|
28.0
|
30
|
2.08
|
25
|
Valnemulin 250
|
3
|
10
|
26.2
|
22
|
2.61
|
6
|
Tylosin 500
|
52
|
50
|
26.2
|
22
|
2.38
|
15
|
Tilmicosin 75
|
19
|
100
|
25.5
|
19
|
2.27
|
19
|
Lincomycin / spectinomycin 500
|
75
|
100
|
30.6
|
42
|
2.34
|
16
|
Enrofloxacin 50
|
8
|
10
|
27.3
|
27
|
2.34
|
16
|
Chlortetracycline 270
|
41
|
20
|
28.0
|
30
|
2.29
|
18
|
Graph 1. Comparison of air sac lesion scores following a M. gallisepticum artificial infection challenge and treatment with various antimicrobials
Graph 2. Comparison of M. gallisepticum re-isolation following an artificial infection challenge and treatment with various antimicrobials
Conclusions:
Valnemulin gave similar improvements in disease control (air sac lesions and MG re-isolation) and performance (ADG and FCE) to tiamulin and enrofloxacin and better disease control than tylosin, tilmicosin, lincomycin/spectinomycin and chlortetracycline.
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